Hormone Replacement Therapy Research - HRT, Menopause, Natural HRT, Effects, Risks

Hormone Replacement Therapy Research Today is a free monthly online journal that collates and summarizes the latest research about Hormone Replacement Therapy, including details on hrt, menopause, natural hrt, effects, risks.


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Reproductive factors and menopausal hormone therapy and bladder cancer risk in the NIH-AARP Diet and Health Study.

Daugherty SE, Lacey JV, Pfeiffer RM, Park Y, Hoover RN, Silverman DT

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. daughers@mail.nih.gov

The incidence of bladder cancer among women is at least one-third to one-fourth that observed among men in many countries. Even after accounting for known risk factors, the reason for this gender disparity remains unexplained. We conducted a comprehensive evaluation of reproductive factors and exogenous hormone use with a primary focus on menopausal hormone therapy use and risk of bladder cancer in women in the NIH-AARP Diet and Health Study. Reproductive and hormonal factors were ascertained on the baseline questionnaire in 1995-1996 among 201,492 females who were followed until December 31, 2006. During follow-up, 651 cases of bladder cancer were diagnosed. A subset of women provided detailed information on use of MHT in a second questionnaire in 1996-1997. In this analysis, 127,361 females were followed through June 30, 2002 and 198 incident bladder cancer cases were identified. Cox proportional hazard models, adjusted for smoking status, cigarettes per day and body mass index using age as the time metric, were used to obtain hazard ratios (HRs). A reduced risk was observed among parous women (HR=0.76; 95% CI 0.62-0.93) and women who reported late age at menarche (≥15 years) (HR=0.57; 95% CI 0.39-0.84). Women who reported ever using estrogen and progestin therapy had a decreased risk (HR=0.53; 95% CI: 0.34-0.83) compared with women who did not report MHT use. No association was observed for estrogen only users (HR=0.82; 95% CI: 0.58-1.15). Our results suggest a putative role for sex hormones in the etiology of bladder cancer among women.

Published 15 May 2013 in Int J Cancer, 133(2): 462-72.
Full-text of this article is available online (may require subscription).


Articles on Hormone Replacement Therapy published 2 May 2012:

Results from a blind and a non-blind randomised trial run in parallel: experience from the Estonian Postmenopausal Hormone Therapy (EPHT) Trial.   BMC Med Res Methodol, 12: 44.

[Abstract] [Full-text]


Articles on Hormone Replacement Therapy published 1 May 2012:

Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency.   Eur J Endocrinol, 166(5): 787-95.

[Abstract] [Full-text]


Articles on Hormone Replacement Therapy published 16 April 2012:

Breast cancer incidence trends in Norway--explained by hormone therapy or mammographic screening?   Int J Cancer, 130(12): 2930-8.

A decline in breast cancer incidence has been observed in several countries after 2002. Reduced use of menopausal hormonal therapy (HT), as a consequence of the publication of results from the Women's Health Initiative, has been argued to be the main reason. In Norway, the governmentally funded Norwegian Breast Cancer Screening Program (NBCSP) was implemented during the same time period as the increased use of HT. This study investigated trends in breast cancer incidence by use of HT and ... [Abstract] [Full-text]


Articles on Hormone Replacement Therapy published 11 April 2012:

Neurodevelopment in children born to hypothyroid mothers restored to normal thyroxine (T₄) concentration by late pregnancy in Japan: no apparent influence of maternal T₄ deficiency.   J Clin Endocrinol Metab, 97(4): 1104-8.

[Abstract] [Full-text]


Articles on Hormone Replacement Therapy published 4 April 2012:

Changing concepts: Menopausal hormone therapy and breast cancer.   J Natl Cancer Inst, 104(7): 517-27.

Hormone therapy is still used by millions of women for menopausal symptoms. Concerns regarding hormone therapy and breast cancer were initially based on case reports and retrospective case-control studies. However, recent results from large prospective cohort studies and the Women's Health Initiative (WHI) randomized placebo-controlled hormone therapy trials have substantially changed concepts regarding how estrogen alone and estrogen plus progestin influence breast cancer. The preponderance of ... [Abstract] [Full-text]


Articles on Hormone Replacement Therapy published 28 March 2012:

Tissue factor pathway inhibitor, activated protein C resistance, and risk of ischemic stroke due to postmenopausal hormone therapy.   Stroke, 43(4): 952-7.

[Abstract] [Full-text]


Articles on Hormone Replacement Therapy published 26 March 2012:

Physical activity and change in quality of life during menopause--an 8-year follow-up study.   Health Qual Life Outcomes, 10: 8.

[Abstract] [Full-text]


Articles on Hormone Replacement Therapy published 21 March 2012:

Levothyroxine dose following thyroidectomy is affected by more than just body weight.   Laryngoscope, 122(4): 834-8.

[Abstract] [Full-text]


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Hormone Replacement Therapy Research Today Archive:

Volume 1 (2004)
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Volume 2 (2005)
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Volume 3 (2006)
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Volume 5 (2008)
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Volume 6 (2009)
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Volume 7 (2010)
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Volume 8 (2011)
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Volume 9 (2012)
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Volume 10 (2013)
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